Cellular response to follicle-stimulating hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to follicle-stimulating hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL4A3, TMEM255A, and RNA5SP80, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to follicle-stimulating hormone stimulus activity versus COL4A3 in LUAD (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COL4A3 →	-0.813	-0.425	<.001	.001	3	3
LSCC	TMEM255A →	+0.846	+0.936	<.001	<.001	3	3
CCRCC	RNA5SP80 →	+0.545	+0.192	<.001	.007	3	2
CCRCC	RPL23AP2 →	-0.270	-0.112	.004	.002	3	2
CCRCC	LINC02818 →	+0.322	+0.189	.005	.009	3	2
CCRCC	MIR378D2HG →	+0.179	+0.141	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071372 vs COL4A3 — LUAD

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