Cellular response to follicle-stimulating hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to follicle-stimulating hormone stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTO1, SMYD2, and PDCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSTO1 grouped by Cellular response to follicle-stimulating hormone stimulus-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GSTO1 →	-0.109	-0.123	.008	.001	3	5
STOMACH	SMYD2 →	+0.226	+0.128	.002	.006	2	5
OVARY	PDCD1 →	-0.372	-0.118	.004	.004	3	4
KIDNEY	AFF2 →	+0.138	+0.218	.006	.001	3	4
OESOPHAGUS	HNRNPUL1 →	+0.101	+0.217	.009	<.001	3	4
CNS	RPP25 →	+0.286	+0.121	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSTO1 by Cellular response to follicle-stimulating hormone stimulus activity — SKIN

Explore this box plot interactively →