Cellular response to follicle-stimulating hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to follicle-stimulating hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCLM, POR, and PIR, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to follicle-stimulating hormone stimulus activity versus GCLM in LIVER (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GCLM →	+2.207	+0.380	.002	.001	3	10
LARGE_INTESTINE	POR →	+0.972	+0.203	.005	.002	3	8
LUNG_NSCLC_LUAD	PIR →	+2.050	+0.396	<.001	.001	3	6
LIVER	AKR1B10 →	+8.563	+0.429	<.001	<.001	3	5
KIDNEY	AHCYL1 →	+1.264	+0.196	.007	.007	2	6
LUNG_NSCLC_LUAD	EPHX1 →	+1.775	+0.366	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071372 vs GCLM — LIVER

Explore this scatter interactively →