Cellular response to ether

Across TCGA patient cohorts, RNA activity of the Cellular response to ether pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1, TNFAIP8L2, and UNC13D, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ether activity versus FMNL1 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FMNL1 →	+0.635	+0.112	<.001	<.001	3	10
GBM	TNFAIP8L2 →	+0.863	+0.128	<.001	<.001	3	9
LSCC	UNC13D →	+0.561	+0.095	<.001	<.001	3	9
GBM	CCDC88B_S597 →	+0.715	+0.087	<.001	<.001	3	9
BRCA	CYBB →	+0.761	+0.058	<.001	<.001	3	9
LSCC	DOCK2_S1685 →	+0.684	+0.093	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071362 vs FMNL1 — LSCC

Explore this scatter interactively →