Cellular response to ether

Across TCGA cell cohorts, RNA activity of the Cellular response to ether pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCSK6, CRABP2, and UBTD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCSK6 grouped by Cellular response to ether-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCSK6 →	+1.814	+0.284	.004	.005	3	5
LARGE_INTESTINE	CRABP2 →	-2.389	-0.603	.002	.009	3	4
BREAST	UBTD1 →	-0.844	-0.652	.005	.002	3	3
BREAST	KLF6 →	-1.687	-0.711	.001	.005	3	3
LUNG_NSCLC_LUSC	CDK5RAP2 →	+1.484	+0.768	.001	.008	3	3
BONE	CHTOP →	+0.464	+1.410	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCSK6 by Cellular response to ether activity — BLOOD_Leukemia

Explore this box plot interactively →