Cellular response to ether

Across TCGA cell cohorts, RNA activity of the Cellular response to ether pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL4, RPL3, and RPS9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ether activity versus RPL4 in LUNG_SCLC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPL4 →	+0.857	+0.152	<.001	<.001	3	9
STOMACH	RPL3 →	+0.856	+0.255	.001	.008	1	10
LARGE_INTESTINE	RPS9 →	+0.757	+0.256	<.001	<.001	3	8
PANCREAS	RPL6 →	+0.827	+0.265	.001	.009	3	7
BREAST	HNRNPA1 →	+0.656	+0.192	<.001	<.001	3	7
PANCREAS	RPL7 →	+0.955	+0.245	.002	.003	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071362 vs RPL4 — LUNG_SCLC

Explore this scatter interactively →