Cellular response to exogenous dsRNA

Across TCGA patient cohorts, RNA activity of the Cellular response to exogenous dsRNA pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT2, XAF1, and DDX58, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to exogenous dsRNA activity versus STAT2 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STAT2 →	+0.435	+0.074	<.001	<.001	3	9
COAD	XAF1 →	+0.865	+0.059	.004	.002	3	9
OV	DDX58 →	+0.728	+0.072	<.001	<.001	3	9
GBM	DDX60 →	+0.427	+0.085	<.001	<.001	3	9
BRCA	TRIM22 →	+0.525	+0.052	<.001	<.001	3	9
OV	IFIT1 →	+0.916	+0.065	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071360 vs STAT2 — OV

Explore this scatter interactively →