Cellular response to exogenous dsRNA

Across TCGA cell cohorts, RNA activity of the Cellular response to exogenous dsRNA pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIT3, IFIH1, and IFIT2, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to exogenous dsRNA activity versus IFIT3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IFIT3 →	+2.862	+0.195	<.001	<.001	3	16
STOMACH	IFIH1 →	+2.863	+0.219	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	IFIT2 →	+1.931	+0.161	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	IFI44L →	+3.579	+0.192	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	OAS1 →	+2.933	+0.187	<.001	<.001	3	15
URINARY_TRACT	OAS2 →	+3.034	+0.231	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071360 vs IFIT3 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →