Cellular response to exogenous dsRNA

Across TCGA cell cohorts, RNA activity of the Cellular response to exogenous dsRNA pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM1, NIT2, and UBN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LSM1 grouped by Cellular response to exogenous dsRNA-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LSM1 →	+0.425	+0.501	.008	.008	3	4
LUNG_SCLC	NIT2 →	-0.254	-0.142	.004	<.001	3	4
BLOOD_Leukemia	UBN1 →	+0.375	+0.260	.001	<.001	3	3
BLOOD_Leukemia	TRIM25 →	-0.211	-0.207	.008	.003	3	3
OVARY	AP1G2 →	+0.343	+0.175	.007	.005	3	3
CNS	ZFP91-CNTF →	+0.164	+0.107	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LSM1 by Cellular response to exogenous dsRNA activity — BLOOD_Lymphoma

Explore this box plot interactively →