Cellular response to interleukin-1

Across TCGA cell cohorts, RNA activity of the Cellular response to interleukin-1 pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE2, PDK1, and SCAMP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interleukin-1 activity versus CPNE2 in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPNE2 →	+1.727	+0.151	.003	.003	3	5
BONE	PDK1 →	+1.312	+0.305	.001	.004	3	4
BONE	SCAMP1 →	+0.867	+0.224	.004	.001	3	4
STOMACH	AAMDC →	+1.635	+0.236	.009	.005	3	4
LUNG_SCLC	PTP4A2 →	-0.556	-0.133	.001	.001	3	4
CNS	ASXL2 →	+0.431	+0.154	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071347 vs CPNE2 — BLOOD_Leukemia

Explore this scatter interactively →