Skeletal muscle acetylcholine-gated channel clustering

Across TCGA patient cohorts, RNA activity of the Skeletal muscle acetylcholine-gated channel clustering pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OGN, MRPL18, and SGCD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle acetylcholine-gated channel clustering activity versus OGN in PDAC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	OGN →	-0.723	-0.050	<.001	<.001	3	6
UCEC	MRPL18 →	+0.247	+0.095	.001	<.001	3	6
HNSC	SGCD →	-0.764	-0.093	<.001	<.001	3	6
LSCC	MDM1_S601 →	-0.424	-0.052	<.001	<.001	3	6
COAD	TFB2M →	+0.366	+0.040	.001	.005	3	5
COAD	MRPL3 →	+0.200	+0.031	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071340 vs OGN — PDAC

Explore this scatter interactively →