Skeletal muscle acetylcholine-gated channel clustering

Across TCGA patient cohorts, RNA activity of the Skeletal muscle acetylcholine-gated channel clustering pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF439, RASGRP1, and KLRC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle acetylcholine-gated channel clustering activity versus ZNF439 in OV (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF439 →	-0.666	-0.123	.004	.006	3	4
COAD	RASGRP1 →	-0.439	-0.129	<.001	<.001	3	4
BRCA	KLRC1 →	-0.372	-0.096	.003	.004	3	3
BRCA	POMK →	-0.436	-0.133	.005	.001	3	3
CCRCC	GSTT2B →	-0.446	-0.214	.005	.002	2	4
CCRCC	RNF150 →	-0.530	-0.374	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071340 vs ZNF439 — OV

Explore this scatter interactively →