Cellular response to carbohydrate stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to carbohydrate stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARIH1, UBE2CP4, and CDC26, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to carbohydrate stimulus activity versus ARIH1 in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARIH1 →	+0.403	+0.234	.001	.002	3	3
BRCA	UBE2CP4 →	-0.340	-0.138	.007	.008	3	3
CCRCC	CDC26 →	-0.261	-0.169	<.001	<.001	3	3
CCRCC	DIABLO →	+0.329	+0.151	<.001	.002	3	3
CCRCC	RUNDC3A-AS1 →	+0.120	+0.190	<.001	<.001	3	3
CCRCC	GPIHBP1 →	-1.038	-0.162	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071322 vs ARIH1 — BRCA

Explore this scatter interactively →