Cellular response to carbohydrate stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to carbohydrate stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS18B, PPARA, and HOXC13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to carbohydrate stimulus activity versus MRPS18B in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRPS18B →	-0.775	-0.288	.001	.009	3	4
LIVER	PPARA →	+1.393	+0.235	.009	.001	3	4
LUNG_NSCLC_LUSC	HOXC13 →	+2.717	+0.322	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CAPZA1 →	+0.573	+0.177	.002	<.001	3	3
LUNG_NSCLC_LUAD	MICAL2 →	-1.972	-0.179	<.001	.002	3	3
BREAST	CHCHD10 →	+1.245	+0.223	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071322 vs MRPS18B — UPPER_AERODIGESTIVE_TRACT

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