Cellular response to ATP

Across TCGA patient cohorts, RNA activity of the Cellular response to ATP pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX32, KRT18P67, and RN7SKP64, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ATP activity versus DHX32 in PDAC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DHX32 →	-0.325	-0.521	.002	.005	3	3
LUAD	KRT18P67 →	-0.090	-0.546	.002	.009	3	3
LUAD	RN7SKP64 →	-0.555	-0.688	<.001	<.001	3	3
COAD	FAM86KP →	-0.182	-0.578	.003	<.001	3	2
COAD	CALML6 →	+0.195	+0.610	.004	.007	3	2
COAD	RPL17P25 →	-0.144	-0.505	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071318 vs DHX32 — PDAC

Explore this scatter interactively →