Cellular response to nicotine

Across TCGA cell cohorts, RNA activity of the Cellular response to nicotine pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, HLA-B, and PSMB8, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nicotine activity versus B2M in OESOPHAGUS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	B2M →	+2.241	+1.526	<.001	.002	3	12
OESOPHAGUS	HLA-B →	+3.891	+1.638	.001	<.001	3	12
OESOPHAGUS	PSMB8 →	+4.100	+1.507	<.001	.002	3	11
OVARY	HLA-A →	+2.811	+1.322	.006	.001	3	10
CNS	TAP1 →	+2.642	+1.466	.003	<.001	3	9
BREAST	PATL2 →	+1.042	+1.290	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071316 vs B2M — OESOPHAGUS

Explore this scatter interactively →