Cellular response to caffeine

Across TCGA patient cohorts, RNA activity of the Cellular response to caffeine pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM165, GSTM2, and ME1_S336, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to caffeine activity versus TMEM165 in GBM (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM165 →	-0.274	-0.053	.004	.006	3	6
LSCC	GSTM2 →	+0.892	+0.061	<.001	.002	3	5
HNSC	ME1_S336 →	+0.901	+0.143	<.001	<.001	3	5
UCEC	SPARCL1_S59 →	+0.857	+0.050	.001	<.001	3	4
BRCA	TC2N →	-0.667	-0.042	.003	.004	3	4
BRCA	LRRFIP1 →	-0.326	-0.050	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071313 vs TMEM165 — GBM

Explore this scatter interactively →