Cellular response to caffeine

Across TCGA patient cohorts, RNA activity of the Cellular response to caffeine pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUS1, CHEK1, and SLC8A1_S285, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to caffeine activity versus NUS1 in OV (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NUS1 →	-0.674	-1.186	<.001	<.001	3	4
COAD	CHEK1 →	+0.631	+0.460	<.001	<.001	3	3
UCEC	SLC8A1_S285 →	+0.794	+0.988	.003	.003	3	3
OV	PRKCI_S247 →	-1.558	-1.046	<.001	.001	2	4
HNSC	BIN1_T323 →	+1.126	+1.021	<.001	<.001	3	3
HNSC	CAP2 →	+0.538	+0.832	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071313 vs NUS1 — OV

Explore this scatter interactively →