Cellular response to caffeine

Across TCGA cell cohorts, RNA activity of the Cellular response to caffeine pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRELID3B, FAM118B, and ATG4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRELID3B grouped by Cellular response to caffeine-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRELID3B →	-0.832	-1.388	<.001	.001	3	5
BLOOD_Leukemia	FAM118B →	-0.797	-1.189	<.001	<.001	3	5
OVARY	ATG4A →	-0.729	-0.929	.001	.001	3	4
BLOOD_Leukemia	DUS4L →	-0.771	-1.212	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	C4B →	-1.193	-1.044	.003	.004	3	4
BLOOD_Myeloma	INTS12 →	-0.773	-0.545	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRELID3B by Cellular response to caffeine activity — BLOOD_Leukemia

Explore this box plot interactively →