Cellular response to alkaloid

Across TCGA patient cohorts, RNA activity of the Cellular response to alkaloid pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KPNA2, MCM2, and RRM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to alkaloid activity versus KPNA2 in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KPNA2 →	+0.734	+0.047	<.001	<.001	3	8
LUAD	MCM2 →	+0.708	+0.060	<.001	<.001	3	8
LUAD	RRM2 →	+0.794	+0.061	<.001	<.001	3	8
LUAD	RFC1_T506 →	+0.951	+0.064	<.001	<.001	3	7
LUAD	RRP36_S73 →	+0.854	+0.055	<.001	<.001	3	7
BRCA	ATAD2 →	+0.474	+0.026	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071312 vs KPNA2 — OV

Explore this scatter interactively →