Cellular response to alkaloid

Across TCGA patient cohorts, RNA activity of the Cellular response to alkaloid pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5D, CLINT1, and PZP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to alkaloid activity versus GPRC5D in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPRC5D →	-0.679	-0.695	<.001	<.001	3	4
BRCA	CLINT1 →	-0.352	-0.503	.001	.006	3	4
HNSC	PZP →	+0.983	+0.757	<.001	<.001	3	4
HNSC	LANCL1-AS1 →	+0.768	+0.725	<.001	<.001	3	4
HNSC	METTL21EP →	+0.514	+0.564	<.001	.006	3	4
GBM	BTG1P1 →	+0.734	+0.219	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071312 vs GPRC5D — LSCC

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