Cellular response to alkaloid

Across TCGA cell cohorts, RNA activity of the Cellular response to alkaloid pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBFB, MCUB, and CEP78, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to alkaloid activity versus CBFB in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CBFB →	+0.984	+1.407	<.001	<.001	3	6
BLOOD_Leukemia	MCUB →	+1.261	+0.161	.006	<.001	3	5
BLOOD_Leukemia	CEP78 →	+0.940	+0.162	.002	.007	3	5
UPPER_AERODIGESTIVE_TRACT	FGF2 →	+1.270	+0.965	.002	.008	3	5
LIVER	ANKFY1 →	+0.638	+1.143	.002	.008	3	5
OVARY	ATP8B3 →	+1.407	+0.706	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071312 vs CBFB — UPPER_AERODIGESTIVE_TRACT

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