Cellular response to vitamin D

Across TCGA cell cohorts, RNA activity of the Cellular response to vitamin D pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMR1, BAG1, and MS4A4E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FMR1 grouped by Cellular response to vitamin D-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FMR1 →	+0.751	+1.004	<.001	.007	3	4
PANCREAS	BAG1 →	-1.067	-1.131	.001	.003	3	4
BREAST	MS4A4E →	-0.014	-0.846	.001	.002	3	4
URINARY_TRACT	DLL1 →	-2.679	-1.815	<.001	<.001	2	4
URINARY_TRACT	HSD3B7 →	+1.748	+1.563	.001	<.001	3	3
PANCREAS	VPS37B →	-0.959	-1.113	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FMR1 by Cellular response to vitamin D activity — SOFT_TISSUE

Explore this box plot interactively →