Cellular response to vitamin D

Across TCGA cell cohorts, RNA activity of the Cellular response to vitamin D pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100P, FSTL3, and SMS, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100P grouped by Cellular response to vitamin D-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	S100P →	+0.148	+1.122	.002	.005	3	2
LUNG_NSCLC_LUAD	FSTL3 →	-0.190	-1.145	.003	.007	3	2
LUNG_SCLC	SMS →	-0.199	-2.088	<.001	.001	3	2
LUNG_SCLC	MGRN1 →	+0.296	+2.088	.004	.001	3	2
LUNG_SCLC	PLCE1 →	-0.153	-2.088	<.001	.001	3	2
LUNG_SCLC	DHX38 →	+0.910	+2.088	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100P by Cellular response to vitamin D activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →