Cellular response to vitamin D

Across TCGA cell cohorts, RNA activity of the Cellular response to vitamin D pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHA7, KCNK5, and AGTRAP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to vitamin D activity versus PLEKHA7 in LUNG_NSCLC_LUAD (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLEKHA7 →	-2.524	-1.276	.001	.003	3	3
LUNG_SCLC	KCNK5 →	-1.876	-1.725	.003	.001	3	3
LUNG_SCLC	AGTRAP →	-1.569	-1.725	.006	.001	3	3
SKIN	CDC25B →	-0.651	-1.401	.007	.003	2	3
SKIN	GLA →	-1.742	-2.124	.002	<.001	3	2
SKIN	FBL →	-1.284	-2.010	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071305 vs PLEKHA7 — LUNG_NSCLC_LUAD

Explore this scatter interactively →