Cellular response to vitamin

Across TCGA patient cohorts, RNA activity of the Cellular response to vitamin pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC11A, RASAL2-AS1, and CPXM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to vitamin activity versus CLEC11A in OV (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLEC11A →	+0.896	+0.235	<.001	<.001	3	5
OV	RASAL2-AS1 →	+0.386	+0.247	.001	.001	3	5
OV	CPXM2 →	+1.077	+0.216	.004	.003	3	4
LSCC	IRF2BPL →	+0.334	+0.566	.003	.001	3	4
CCRCC	MTA1 →	+0.522	+0.585	<.001	<.001	3	4
CCRCC	KCNJ8 →	+0.616	+0.368	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071295 vs CLEC11A — OV

Explore this scatter interactively →