Cellular response to vitamin

Across TCGA cell cohorts, RNA activity of the Cellular response to vitamin pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT80, BPNT2, and SMIM8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT80 grouped by Cellular response to vitamin-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IFT80 →	-0.787	-1.430	.001	<.001	3	4
KIDNEY	BPNT2 →	-0.824	-1.193	.005	<.001	3	4
BLOOD_Leukemia	SMIM8 →	-0.643	-1.119	<.001	<.001	3	4
LUNG_SCLC	PPP2R5E →	-0.594	-1.140	.007	<.001	3	3
LUNG_SCLC	C5orf22 →	-0.985	-1.531	.005	.001	3	3
STOMACH	TXN →	-1.154	-1.378	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT80 by Cellular response to vitamin activity — LARGE_INTESTINE

Explore this box plot interactively →