Cellular response to manganese ion

Across TCGA cell cohorts, RNA activity of the Cellular response to manganese ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GANAB, DERA, and UTP15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to manganese ion activity versus GANAB in BLOOD_Lymphoma (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GANAB →	+0.541	+0.146	.006	<.001	2	6
CNS	DERA →	+0.491	+0.111	.006	.008	3	4
LARGE_INTESTINE	UTP15 →	+0.767	+0.120	<.001	.006	3	4
URINARY_TRACT	ZNF430 →	+0.807	+0.371	.007	.001	3	4
URINARY_TRACT	HELLS →	+1.268	+0.362	<.001	<.001	3	4
BREAST	PLK4 →	+0.622	+0.126	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071287 vs GANAB — BLOOD_Lymphoma

Explore this scatter interactively →