Cellular response to lead ion

Across TCGA patient cohorts, RNA activity of the Cellular response to lead ion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PZP, SLCO2B1, and GPX3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to lead ion activity versus PZP in HNSC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PZP →	-1.182	-0.584	<.001	<.001	3	4
HNSC	SLCO2B1 →	-0.553	-0.387	.008	<.001	3	4
PDAC	GPX3 →	-0.496	-0.596	.003	.002	3	4
HNSC	GYPC →	-0.707	-0.373	<.001	.006	3	4
LSCC	DLG2 →	-0.604	-0.592	<.001	.001	3	4
LSCC	SYNE3 →	-0.725	-0.731	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071284 vs PZP — HNSC

Explore this scatter interactively →