Cellular response to copper ion

Across TCGA patient cohorts, RNA activity of the Cellular response to copper ion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM12_S420, AKAP12_T1116, and LMNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to copper ion activity versus RBM12_S420 in PDAC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RBM12_S420 →	-1.124	-0.104	<.001	<.001	3	6
BRCA	AKAP12_T1116 →	+0.797	+0.054	.003	<.001	3	6
HNSC	LMNB1 →	-0.258	-0.058	<.001	<.001	3	6
OV	MT1F →	+1.201	+0.095	<.001	<.001	3	6
PDAC	RBM14 →	-0.359	-0.072	<.001	<.001	3	6
GBM	SNW1 →	-0.269	-0.079	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071280 vs RBM12_S420 — PDAC

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