Cellular response to copper ion

Across TCGA patient cohorts, RNA activity of the Cellular response to copper ion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBOAT1, ITCH-IT1, and C14orf178, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to copper ion activity versus MBOAT1 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MBOAT1 →	-0.488	-0.411	.009	.007	3	3
COAD	ITCH-IT1 →	+0.262	+0.487	.002	.005	3	3
OV	C14orf178 →	+0.227	+0.646	<.001	<.001	3	3
UCEC	SPOCD1 →	+0.495	+0.611	.001	.003	3	3
UCEC	ASRGL1 →	-1.045	-0.927	<.001	<.001	3	3
LUAD	MT1H →	+1.031	+0.368	<.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071280 vs MBOAT1 — LSCC

Explore this scatter interactively →