Cellular response to calcium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to calcium ion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC5, RFC1, and WDR18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to calcium ion activity versus RFC5 in LSCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC5 →	-0.333	-0.043	<.001	<.001	3	7
LSCC	RFC1 →	-0.331	-0.048	<.001	<.001	3	6
OV	WDR18 →	-0.391	-0.024	<.001	.001	3	6
GBM	RBM25 →	-0.330	-0.070	<.001	<.001	3	6
LSCC	WDR12 →	-0.323	-0.034	.001	<.001	3	6
PDAC	XPOT →	-0.128	-0.016	.008	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071277 vs RFC5 — LSCC

Explore this scatter interactively →