Cellular response to calcium ion

Across TCGA patient cohorts, RNA activity of the Cellular response to calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGD3, POLE2, and NFATC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to calcium ion activity versus FGD3 in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FGD3 →	+0.557	+0.306	<.001	<.001	3	4
LSCC	POLE2 →	-0.626	-0.258	.004	.004	2	5
LSCC	NFATC2 →	+0.654	+0.186	.001	.002	3	4
LSCC	KPNB1 →	-0.344	-0.223	.004	.001	3	4
LSCC	TRAT1 →	+0.807	+0.195	<.001	<.001	3	4
LSCC	SKA3 →	-0.623	-0.234	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071277 vs FGD3 — LSCC

Explore this scatter interactively →