Cellular response to calcium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTURN, GGA1, and TAB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTURN grouped by Cellular response to calcium ion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MTURN →	-0.823	-1.288	<.001	<.001	3	5
SOFT_TISSUE	GGA1 →	-0.806	-0.929	<.001	.007	3	4
SOFT_TISSUE	TAB1 →	-0.330	-1.232	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	AGAP5 →	-0.997	-0.943	.005	.008	3	4
BLOOD_Leukemia	NHLRC4 →	+1.370	+1.586	<.001	<.001	3	4
OVARY	C1QTNF6 →	-1.422	-0.897	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTURN by Cellular response to calcium ion activity — CNS

Explore this box plot interactively →