Cellular response to mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR4, ETV6, and TLR1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to mechanical stimulus activity versus TLR4 in THYM (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	TLR4 →	+1.288	+0.048	<.001	<.001	3	29
TGCT	ETV6 →	+0.972	+0.033	<.001	<.001	3	29
CHOL	TLR1 →	+1.482	+0.046	<.001	<.001	3	29
SCLC	SLFN5 →	+1.433	+0.089	<.001	<.001	3	28
THYM	SAMD4A →	+1.370	+0.044	<.001	<.001	3	28
UVM	ELOCP19 →	+1.118	+0.019	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071260 vs TLR4 — THYM

Explore this scatter interactively →