Cellular response to arsenic-containing substance

Across TCGA patient cohorts, RNA activity of the Cellular response to arsenic-containing substance pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBL, SPINT1-AS1, and MAP4K1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to arsenic-containing substance activity versus CBL in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CBL →	+0.265	+0.120	.009	<.001	3	3
LUAD	SPINT1-AS1 →	-0.499	-0.104	.001	.005	3	3
UCEC	MAP4K1 →	+0.700	+0.241	<.001	.007	3	2
OV	TMEM106B →	-0.484	-0.411	.001	.006	3	2
LUAD	BLVRA →	-0.433	-0.132	<.001	.008	3	2
LUAD	PHYH →	-0.428	-0.124	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071243 vs CBL — LUAD

Explore this scatter interactively →