Cellular response to ammonium ion

Across TCGA cell cohorts, RNA activity of the Cellular response to ammonium ion pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB29, DMRT3, and CDHR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB29 grouped by Cellular response to ammonium ion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RAB29 →	+0.183	+0.874	<.001	.009	3	4
SKIN	DMRT3 →	+0.188	+1.079	<.001	.002	3	4
LARGE_INTESTINE	CDHR5 →	-0.168	-0.186	.008	.005	3	3
CNS	CILK1 →	-0.160	-0.495	.002	.001	3	3
BLOOD_Lymphoma	BDKRB2 →	+0.187	+0.144	.006	.001	2	4
KIDNEY	CPM →	-0.180	-1.265	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB29 by Cellular response to ammonium ion activity — SKIN

Explore this box plot interactively →