Cellular response to antibiotic

Across TCGA patient cohorts, RNA activity of the Cellular response to antibiotic pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN_S2116, TLN1, and SORBS3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to antibiotic activity versus VCAN_S2116 in PDAC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VCAN_S2116 →	+0.963	+0.052	.001	.002	3	8
LSCC	TLN1 →	+0.227	+0.047	<.001	<.001	3	8
BRCA	SORBS3 →	+0.304	+0.036	<.001	<.001	3	8
COAD	COLEC12 →	+0.979	+0.052	<.001	<.001	3	7
LSCC	MRC2 →	+0.446	+0.057	<.001	<.001	3	7
UCEC	RSU1 →	+0.434	+0.087	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071236 vs VCAN_S2116 — PDAC

Explore this scatter interactively →