Cellular response to antibiotic

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to antibiotic pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Cellular response to antibiotic pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and PCPG, show the opposite pattern, with higher activity associated with better survival.

HNSC, LGG, and LAML are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.718	0.606	.003	105	view →
LGG	OS	Median	All	0.359	0.558	<.001	54	view →
LAML	DFS	Median	All	0.367	0.725	<.001	36	view →
COAD	DFS	Median	IV	0.297	0.617	.001	34	view →
KIRC	DFS	Quartile	All	0.469	0.739	<.001	28	view →
DLBC	OS	Quartile	All	0.484	1.000	.018	20	view →
KICH	DFS	Median	II,III,IV	0.568	1.000	.005	19	view →
UVM	DFS	Quartile	III,IV	0.163	0.813	<.001	16	view →
SKCM	DFS	Median	II,III,IV	0.485	0.673	.006	15	view →
PCPG	DFS	Median	All	1.000	0.690	.003	14	view →
BRCA	DFS	Median	III,IV	0.646	0.385	.001	14	view →
READ	DFS	Median	III,IV	0.333	0.776	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0071236–HNSC (OS)

Open the HNSC breakdown →