Cellular response to antibiotic

Across TCGA cell cohorts, RNA activity of the Cellular response to antibiotic pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED26, GNA11, and AKT1S1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED26 grouped by Cellular response to antibiotic-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MED26 →	-0.510	-0.318	<.001	<.001	3	5
LIVER	GNA11 →	+0.381	+0.263	.002	.003	3	5
URINARY_TRACT	AKT1S1 →	+0.210	+0.367	.008	.002	3	5
LIVER	PDE1C →	-0.391	-0.243	<.001	.009	3	4
OESOPHAGUS	CHRNG →	+0.226	+0.268	.001	<.001	3	4
OESOPHAGUS	CAPZB →	-0.573	-0.191	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED26 by Cellular response to antibiotic activity — LIVER

Explore this box plot interactively →