Cellular response to antibiotic

Across TCGA cell cohorts, RNA activity of the Cellular response to antibiotic pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC34, HSD11B1L, and REXO2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to antibiotic activity versus TTC34 in BLOOD_Leukemia (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TTC34 →	+0.195	+2.134	.008	.002	3	3
BLOOD_Lymphoma	HSD11B1L →	+1.184	+0.294	.009	.007	3	3
OESOPHAGUS	REXO2 →	-0.876	-2.017	.001	<.001	3	3
BLOOD_Leukemia	GRAMD1B →	+4.160	+2.038	<.001	<.001	3	2
BLOOD_Leukemia	RIMBP3B →	+0.659	+1.467	.007	.009	3	2
BLOOD_Lymphoma	ARHGAP26 →	+1.875	+0.323	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071236 vs TTC34 — BLOOD_Leukemia

Explore this scatter interactively →