Resolution of DNA recombination intermediates

Across TCGA patient cohorts, RNA activity of the Resolution of DNA recombination intermediates pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF23, CENPO, and ZGRF1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Resolution of DNA recombination intermediates activity versus KIF23 in MESO (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	KIF23 →	+1.821	+0.074	<.001	<.001	3	33
LIHC	CENPO →	+0.952	+0.059	<.001	<.001	3	33
THYM	ZGRF1 →	+1.006	+0.077	<.001	<.001	3	33
MESO	TICRR →	+1.273	+0.079	<.001	<.001	3	33
MESO	DDIAS →	+1.109	+0.078	<.001	<.001	3	33
THYM	ATAD5 →	+1.083	+0.078	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071139 vs KIF23 — MESO

Explore this scatter interactively →