Resolution of DNA recombination intermediates

Across TCGA pan-cancer cohorts, RNA activity of the Resolution of DNA recombination intermediates pathway is associated with patient survival in 29 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Resolution of DNA recombination intermediates pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and THYM, show the opposite pattern, with higher activity associated with better survival.

MESO, ACC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.394	0.686	<.001	159	view →
ACC	OS	Tertile	All	0.394	0.819	<.001	135	view →
KIRP	OS	Median	All	0.600	0.770	<.001	130	view →
KIRC	OS	Median	All	0.512	0.720	<.001	122	view →
KICH	OS	Tertile	III,IV	0.255	0.871	.001	89	view →
LIHC	OS	Median	All	0.593	0.769	<.001	83	view →
LGG	OS	Median	All	0.731	0.881	<.001	52	view →
LUAD	DFS	Tertile	All	0.729	0.850	<.001	40	view →
UVM	OS	Tertile	III,IV	0.199	1.000	<.001	39	view →
UCS	DFS	Quartile	II,III,IV	0.733	0.180	.009	36	view →
SARC	DFS	Quartile	All	0.490	0.705	.001	36	view →
PAAD	DFS	Quartile	All	0.360	0.584	.003	35	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

GO:0071139–MESO (OS)

Open the MESO breakdown →