Resolution of DNA recombination intermediates

Across TCGA patient cohorts, RNA activity of the Resolution of DNA recombination intermediates pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIF1, BLM, and NT5M, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Resolution of DNA recombination intermediates activity versus PIF1 in GBM (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIF1 →	+0.854	+0.240	<.001	<.001	3	5
LSCC	BLM →	+0.844	+0.354	<.001	.001	3	5
BRCA	NT5M →	+0.779	+0.146	<.001	.002	3	4
HNSC	NANOGNBP3 →	+0.759	+0.140	<.001	.008	3	4
GBM	CENPI →	+0.792	+0.199	<.001	<.001	3	4
BRCA	CCNE1 →	+1.097	+0.223	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071139 vs PIF1 — GBM

Explore this scatter interactively →