Resolution of DNA recombination intermediates

Across TCGA patient cohorts, RNA activity of the Resolution of DNA recombination intermediates pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RMI1, UNG_S23, and KNTC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Resolution of DNA recombination intermediates activity versus RMI1 in GBM (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RMI1 →	+0.721	+0.250	<.001	<.001	3	6
GBM	UNG_S23 →	+1.034	+0.291	<.001	<.001	3	4
GBM	KNTC1 →	+0.551	+0.255	<.001	<.001	3	4
LSCC	NUF2 →	+0.614	+0.376	<.001	.007	3	4
LSCC	PHF3_S1133 →	+0.541	+0.391	<.001	<.001	3	4
COAD	TOP3A →	+0.877	+0.250	.001	.003	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071139 vs RMI1 — GBM

Explore this scatter interactively →