Resolution of DNA recombination intermediates

Across TCGA cell cohorts, RNA activity of the Resolution of DNA recombination intermediates pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC3, TOP3A, and RMI1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XRCC3 grouped by Resolution of DNA recombination intermediates-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	XRCC3 →	-0.279	-1.080	<.001	<.001	3	8
OVARY	TOP3A →	-0.175	-0.785	.007	.009	3	8
LUNG_SCLC	RMI1 →	-0.273	-1.747	<.001	<.001	3	8
LUNG_NSCLC_LUAD	BLM →	-0.165	-0.897	.006	.003	3	6
BLOOD_Leukemia	TNNI3 →	+0.160	+1.151	.007	.003	3	5
BREAST	RMI2 →	-0.263	-1.021	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XRCC3 by Resolution of DNA recombination intermediates activity — CNS

Explore this box plot interactively →