Resolution of DNA recombination intermediates

Across TCGA cell cohorts, RNA activity of the Resolution of DNA recombination intermediates pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCXR, RASA3, and PSAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCXR grouped by Resolution of DNA recombination intermediates-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DCXR →	-0.973	-1.304	<.001	.001	3	4
BLOOD_Leukemia	RASA3 →	+1.112	+1.022	.006	.001	3	4
LUNG_NSCLC_LUSC	PSAP →	-1.058	-1.033	<.001	.006	3	3
STOMACH	UCHL5 →	+0.718	+1.318	.005	.006	3	3
CNS	CYBB →	-0.149	-0.536	.006	.007	3	3
CNS	SCAMP5 →	-1.124	-0.689	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCXR by Resolution of DNA recombination intermediates activity — STOMACH

Explore this box plot interactively →