Resolution of DNA recombination intermediates

Across TCGA cell cohorts, RNA activity of the Resolution of DNA recombination intermediates pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HACE1, MNDA, and SMURF1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HACE1 grouped by Resolution of DNA recombination intermediates-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HACE1 →	-0.193	-0.256	.005	.001	3	2
BLOOD_Leukemia	MNDA →	+0.078	+0.251	.005	.001	3	2
BLOOD_Leukemia	SMURF1 →	+0.143	+0.256	<.001	.001	3	2
BREAST	NDUFB4 →	-0.354	-0.511	.006	.002	3	2
LUNG_SCLC	SIAE →	-0.126	-1.224	.002	.004	3	2
LUNG_NSCLC_LUAD	ARHGAP8 →	-0.268	-0.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HACE1 by Resolution of DNA recombination intermediates activity — BLOOD_Leukemia

Explore this box plot interactively →