Protein K48-linked deubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K48-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC6, SNAI3, and ARMCX3-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K48-linked deubiquitination activity versus CDC6 in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDC6 →	+0.505	+0.378	.009	.005	3	4
PDAC	SNAI3 →	-0.353	-0.833	.004	<.001	2	4
PDAC	ARMCX3-AS1 →	-0.190	-0.675	<.001	<.001	3	3
HNSC	KIF2C →	+0.870	+0.745	.003	<.001	3	3
HNSC	EXO1 →	+0.608	+0.541	.007	.005	3	3
UCEC	PCNA →	+0.751	+0.464	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071108 vs CDC6 — LUAD

Explore this scatter interactively →