Protein K48-linked deubiquitination

Across TCGA pan-cancer cohorts, RNA activity of the Protein K48-linked deubiquitination pathway differs between tumor and matched normal tissue in 6 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH, show the opposite pattern, with lower activity in tumor tissue.

COAD, KICH, and CHOL show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	II,III,IV	+0.030	<.001	5	view →
KICH	All	All	−0.021	<.001	5	view →
CHOL	All	All	+0.041	.020	4	view →
HNSC	All	All	+0.014	.011	4	view →
BLCA	Male	All	+0.042	.025	2	view →
PRAD	All	All	+0.018	.002	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 6 strongest of 6 lineages.

GO:0071108–COAD

Open the COAD breakdown →